Greater effect of stroke thrombolysis in the presence of arterial obstruction

DA De Silva; L Churilov; JM Olivot; S Christensen; MG Lansberg; M Mlynash; BCV Campbell; P Desmond; M Straka; R Bammer; GW Albers; SM Davis; GA Donnan

Journal article

Greater effect of stroke thrombolysis in the presence of arterial obstruction

DA De Silva, L Churilov, JM Olivot, S Christensen, MG Lansberg, M Mlynash, BCV Campbell, P Desmond, M Straka, R Bammer, GW Albers, SM Davis, GA Donnan

Annals of Neurology | WILEY-BLACKWELL | Published : 2011

DOI: 10.1002/ana.22444

Abstract

Recanalization of arterial obstruction is associated with improved clinical outcomes. There are no controlled data demonstrating whether arterial obstruction status predicts the treatment effect of intravenous (IV) tissue plasminogen activator (tPA). We aimed to determine if the presence of arterial obstruction improves the treatment effect of IV tPA over placebo in attenuating infarct growth. Methods: We analyzed 175 ischemic stroke patients treated in the 3-6 hour time window from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) trial (randomized to IV tPA or placebo) and Diffusion and perfusion imaging Evaluation For Understanding Stroke Evolution (DEFUSE) study (all treated..

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University of Melbourne Researchers

Leonid Churilov Author

Bruce Campbell Author

Patricia Desmond Author

Stephen Davis Author

Related Projects (1)

2007 PROGRAM GRANT - (IMPROVING STROKE OUTCOMES: NEW TARGETS AND THERAPIES)

Previously we established a unique collaboration of researchers from the basic and clinical sciences.. The main aim of this ' vertically int..

Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

[ "This research was supported by grants from National Health and Medical Research Council, Australia; National Stroke Foundation, Australia; Heart Foundation of Australia. Australia; NIH, National Institute on Neurological Disorders and Stroke.", "National Health and Medical Research Council, Australia (Programme Grant 454417, GAD, SMD). Support from the National Stroke Foundation, Australia and the Heart Foundation of Australia. NIH, National Institute on Neurological Disorders and Stroke (RO1 NS3935, GWA)." ]